Chondrocalcinosis, as genome-wide studies have reported it: 4 positions from 1 study, the largest recording 3,282 cases and 625,577 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Genome-wide studies have so far placed 4 positions on Chondrocalcinosis, from 1 study; the GWAS Catalog files the condition as "Chondrocalcinosis (PheCode 274.21)". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 3,282 cases and 625,577 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). From it, 4 positions on this page: rs1886248 (RNF144B), rs563754588 (LINC00992), rs184704854 (near RPL21P59), rs200294323 (DAGLA). PMID:39024449.
The catalogue maps the 4 positions to 4 genes: RNF144B, LINC00992, RPL21P59, DAGLA. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
The strongest association in the records is rs1886248 in RNF144B, reported by Verma A et al. 2024 at P = 3 × 10-43.
Read this page as a list of findings about Chondrocalcinosis, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Chondrocalcinosis is diagnosed by a clinician — not from a genotype. None of the 4 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Chondrocalcinosis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Chondrocalcinosis. MyGeneLog™. https://www.mygenelog.com/conditions/chondrocalcinosis
In the GWAS Catalog, Chondrocalcinosis is filed as "Chondrocalcinosis (PheCode 274.21)". Rather than define it, this page lists the genome-wide findings: 4 positions from 1 study, each with its study's sample and citation.
Genes play a part: 4 positions have been linked to it, the largest study recording 3,282 cases and 625,577 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 4 genes: RNF144B, LINC00992, RPL21P59, DAGLA. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Chondrocalcinosis from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.