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Cardioembolic Stroke, as genome-wide studies have reported it: 3 positions from 2 studies, the largest recording 10,804 cases and 1,234,808 controls (European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
What this condition connects to
Prevalence
No prevalence figure appears here: a study's sample size is not a measure of how common a condition is. The largest sample behind this page was 10,804 cases and 1,234,808 controls (European ancestry) (Mishra A et al. 2022, PMID:36180795).
Inheritance
Polygenic in the records: 3 positions at genome-wide significance across 2 studies, each common variant of small effect. Nothing here says how much of the condition is inherited.
2 studies in the GWAS Catalog report 3 positions for Cardioembolic Stroke, which the catalogue files as "Cardioembolic stroke (MTAG)". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Where the positions come from
Cárcel-Márquez J et al. 2022, in Frontiers in Cardiovascular Medicine — A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype. Sample in the catalogue's record: 362,661 individuals (European ancestry). It contributes 2 positions: rs74399915 (KCNJ5-AS1), rs12260801 (RBM20). PMID:35872910.
Mishra A et al. 2022, in Nature — Stroke genetics informs drug discovery and risk prediction across ancestries. The catalogue records its sample as 10,804 cases and 1,234,808 controls (European ancestry). It contributes one position: rs12415501 (NEURL1). PMID:36180795.
Where they lie in the genome
The 3 positions sit in or beside 3 genes: KCNJ5-AS1, RBM20, NEURL1. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
The strongest association in the records is rs74399915 in KCNJ5-AS1, reported by Cárcel-Márquez J et al. 2022 at P = 10-15.
What this page is, and is not
It is a record of what genome-wide studies have reported about Cardioembolic Stroke, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Clinical detail
What is actually diagnosed and treated here
Nothing on this page diagnoses Cardioembolic Stroke. The 3 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
Related variants MyGeneLog™ checks for
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Cardioembolic Stroke comes down to these specific, well-studied positions — not a diagnosis.
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Quoting this page
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In the GWAS Catalog, Cardioembolic Stroke is filed as "Cardioembolic stroke (MTAG)". Rather than define it, this page lists the genome-wide findings: 3 positions from 2 studies, each with its study's sample and citation.
Is Cardioembolic Stroke genetic?
Genes play a part: 3 positions have been linked to it, the largest study recording 10,804 cases and 1,234,808 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
Which genes are linked to Cardioembolic Stroke on this page?
The positions lie in or near 3 genes: KCNJ5-AS1, RBM20, NEURL1. A mapped gene is the catalogue's location for a position, not a mechanism.
Can these variants predict whether I will get Cardioembolic Stroke?
No. They are population-level findings of small effect. Cardioembolic Stroke is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.