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Brugada Syndrome, as genome-wide studies have reported it: 6 positions from 2 studies, the largest recording 2,820 cases and 10,001 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
What this condition connects to
Prevalence
Not taken from these records, which report study sizes rather than how common the condition is. The largest study behind this page recorded 2,820 cases and 10,001 controls (European ancestry) (Barc J et al. 2022, PMID:35210625).
Inheritance
The records show a polygenic pattern — 6 positions from 2 studies, each a common variant of small effect. How much of Brugada Syndrome is inherited is not something they measure.
Brugada Syndrome — filed in the GWAS Catalog as "Brugada syndrome" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 6 positions from 2 studies, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Where the positions come from
Barc J et al. 2022, in Nature Genetics — Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Sample in the catalogue's record: 2,820 cases and 10,001 controls (European ancestry). The 4 positions on this page from it: rs7433206 (SCN5A), rs34760424 (SCN5A), rs41310232 (SCN5A), rs11645463 (IRX3). PMID:35210625.
Ishikawa T et al. 2024, in European Heart Journal — Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci. Sample in the catalogue's record: 940 cases and 1,634 controls (East Asian ancestry). From it, 2 positions on this page: rs6810361 (EXOG), rs7105159 (WT1-AS). PMID:38747976.
The positions
The 6 positions lie in or near 4 genes: SCN5A, IRX3, EXOG, WT1-AS. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Barc J et al. 2022 reported the smallest P value on this page — P = 10-23, with an odds ratio of 1.48 — at rs7433206 in SCN5A.
What this page is, and is not
Read this page as a list of findings about Brugada Syndrome, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Clinical detail
What is actually diagnosed and treated here
Brugada Syndrome is diagnosed by a clinician — not from a genotype. None of the 6 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
Related variants MyGeneLog™ checks for
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Brugada Syndrome comes down to these specific, well-studied positions — not a diagnosis.
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Quoting this page
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In the GWAS Catalog, Brugada Syndrome is filed as "Brugada syndrome". Rather than define it, this page lists the genome-wide findings: 6 positions from 2 studies, each with its study's sample and citation.
Is Brugada Syndrome genetic?
Genome-wide studies have reported 6 associated positions; the largest study behind this page recorded 2,820 cases and 10,001 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
Which genes are linked to Brugada Syndrome on this page?
The catalogue maps the positions to 4 genes: SCN5A, IRX3, EXOG, WT1-AS. These are where the positions sit, not proof of how they act.
Can these variants predict whether I will get Brugada Syndrome?
No. They are population-level findings of small effect. Brugada Syndrome is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.