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Autoimmune neurological syndromes with anti-GAD65 autoantibodies

OR2I1 · rs378956

Where this position leads

Condition: Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies

rs378956 Condition: Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies Autoimmune Neurological Syndromes w… Condition rs378956 rs378956 OR2I1

What the study found

Who was studied 167 German ancestry cases, 1,047 German ancestry controls.

The effect Each copy of the C allele carried 0.32 times the odds of Autoimmune neurological syndromes with anti-GAD65 autoantibodies (95% confidence interval 0.2305-0.434); p = 1 × 10−12.

Where it sits Chromosome 6, band 6p22.1 — in the 3′ untranslated region of OR2I1.

What each result means

C/C Two copies of the version the research linked to Autoimmune neurological syndromes with anti-GAD65 autoantibodies. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Autoimmune neurological syndromes with anti-GAD65 autoantibodies. That is a smaller link than two copies.
T/T No copy of the version the research linked to Autoimmune neurological syndromes with anti-GAD65 autoantibodies. This is the starting point the study compared everyone against.
Source
A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies
Strippel C, Herrera-Rivero M, Wendorff M, Tietz AK, Degenhardt F, Witten A, Schroeter C, Nelke C, Golombeck KS, Madlener M, Rüber T, Ernst L
and 57 more — show all
Racz A, Baumgartner T, Widman G, Doppler K, Thaler F, Siebenbrodt K, Dik A, Kerin C, Räuber S, Gallus M, Kovac S, Grauer OM, Grimm A, Prüss H, Wickel J, Geis C, Lewerenz J, Goebels N, Ringelstein M, Menge T, Tackenberg B, Kellinghaus C, Bien CG, Kraft A, Zettl U, Ismail FS, Ayzenberg I, Urbanek C, Sühs KW, Tauber SC, Mues S, Körtvélyessy P, Markewitz R, Paliantonis A, Elger CE, Surges R, Sommer C, Kümpfel T, Gross CC, Lerche H, Wellmer J, Quesada CM, Then Bergh F, Wandinger KP, Becker AJ, Kunz WS, Meyer Zu Hörste G, Malter MP, Rosenow F, Wiendl H, Kuhlenbäumer G, Leypoldt F, Lieb W, Franke A, Meuth SG, Stoll M, Melzer N
German Network for Research on Autoimmune Encephalitis (GENERATE)
Brain : a journal of neurology · 2023 · PMID 35348614 · open access

Questions about rs378956

What is rs378956?

rs378956 is a single position in the genome, in or near the OR2I1 gene. Published research associates it with autoimmune neurological syndromes with anti-gad65 autoantibodies. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs378956 linked to?

On MyGeneLog this position is linked to Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies. The research behind each link, and its sources, are set out on that condition page.

Does having rs378956 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs378956 come from?

GWAS Catalog, Brain : a journal of neurology 2023, PMID:35348614. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Autoimmune neurological syndromes with anti-GAD65 autoantibodies (rs378956). MyGeneLog™. https://www.mygenelog.com/variants/rs378956

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