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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 4,492 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.155 lower (95% confidence interval 0.1-0.21); p = 3 × 10−8.
Where it sits Chromosome 1, band 1q25.1 — in an intron of TNR.
What each result means
A/ATwo copies of the version the research linked to Lysophosphatidylethanolamine (18:0) [sn2] levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Lysophosphatidylethanolamine (18:0) [sn2] levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Lysophosphatidylethanolamine (18:0) [sn2] levels. This is the starting point the study compared everyone against.
Nature communications · 2022 · PMID 35668104 · open access
Questions about rs9988641
What is rs9988641?
rs9988641 is a single position in the genome, in or near the TNR gene. Published research associates it with lysophosphatidylethanolamine (18:0) [sn2] levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs9988641 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9988641 come from?
GWAS Catalog, Nature communications 2022, PMID:35668104. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license