Who was studied 16,480 European ancestry cases, 1,936,173 European ancestry controls.
The effect
Each copy of the C allele carried 1.15 times the odds of Essential tremor (95% confidence interval 1.12-1.18); p = 5 × 10−24.
Where it sits Chromosome 21, band 21q22.2 — in an intron of LINC00323.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Essential tremor compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Essential tremor.
T/TPublished research associates this genotype with typical/baseline likelihood of Essential tremor — no copies of the reported risk allele.
Communications biology · 2024 · PMID 38671141 · open access
Questions about rs9980363
What is rs9980363?
rs9980363 is a single position in the genome, in or near the LINC00323 gene. Published research associates it with essential tremor. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9980363 linked to?
On MyGeneLog this position is linked to Essential Tremor. The research behind each link, and its sources, are set out on that condition page.
Does having rs9980363 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9980363 come from?
GWAS Catalog, Communications biology 2024, PMID:38671141. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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