ERG · rs9976326
Where this position leads
Condition: Acute Lymphoblastic Leukemia
What the study found
Who was studied 5,321 European ancestry cases, 16,666 European ancestry controls; replicated in 2,237 cases, 3,461 controls.
The effect Each copy of the T allele carried 1.19 times the odds of B-cell acute lymphoblastic leukaemia (95% confidence interval 1.12-1.26); p = 1 × 10−8.
How common The T allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 21, band 21q22.2 — in an intron of ERG.
rs9976326 is a single position in the genome, in or near the ERG gene. Published research associates it with b-cell acute lymphoblastic leukaemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Acute Lymphoblastic Leukemia. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2019, PMID:31767839. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
B-cell acute lymphoblastic leukaemia (rs9976326). MyGeneLog™. https://www.mygenelog.com/variants/rs9976326