Standard

Age-related macular degeneration

CLUL1 · rs9973159

Where this position leads

Condition: Age-Related Macular Degeneration

rs9973159 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs9973159 rs9973159 CLUL1

What the study found

Who was studied 57,290 European ancestry cases, 324,430 European ancestry controls, 2,302 African American cases, 29,223 African American controls, 1,656 Hispanic or Latin American cases, 10,819 Hispanic or Latin American controls.

The effect Each copy of the T allele shifted the measure 0.0967 higher (95% confidence interval 0.075-0.118); p = 2 × 10−18.

How common The T allele had a frequency of about 87% in the people studied.

Where it sits Chromosome 18, band 18p11.32 — in an intron of CLUL1.

What each result means

C/C No copy of the version the research linked to Age-related macular degeneration. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Age-related macular degeneration. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Age-related macular degeneration. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9973159

What is rs9973159?

rs9973159 is a single position in the genome, in or near the CLUL1 gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9973159 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs9973159 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9973159 come from?

GWAS Catalog, Nature genetics 2024, PMID:39623103. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Age-related macular degeneration (rs9973159). MyGeneLog™. https://www.mygenelog.com/variants/rs9973159

← See all variants