Standard

Leukocyte telomere length

TERF2 · rs9939870

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 130,246 European ancestry individuals, 5,075 Bangladeshi ancestry individuals, 23,096 Singaporean Chinese ancestry individuals, 5,683 Asian ancestry individuals, 29,260 African ancestry individuals, 18,019 Hispanic/Latino individuals.

The effect Each copy of the T allele shifted the measure 0.0334 standard deviation unit higher (95% confidence interval 0.026608-0.0401); p = 4 × 10⁻²².

How common The T allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 16, band 16q22.1 — in an intron of TERF2.

What each result means

C/C No copy of the version the research linked to Leukocyte telomere length. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Leukocyte telomere length. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Leukocyte telomere length. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

Keener R, Chhetri SB, Connelly CJ, Taub MA, Conomos MP, Weinstock J, Ni B, Strober B, Aslibekyan S, Auer PL, Barwick L, Becker LC

and 86 more — show all

Blangero J, Bleecker ER, Brody JA, Cade BE, Celedon JC, Chang YC, Cupples LA, Custer B, Freedman BI, Gladwin MT, Heckbert SR, Hou L, Irvin MR, Isasi CR, Johnsen JM, Kenny EE, Kooperberg C, Minster RL, Naseri T, Viali S, Nekhai S, Pankratz N, Peyser PA, Taylor KD, Telen MJ, Wu B, Yanek LR, Yang IV, Albert C, Arnett DK, Ashley-Koch AE, Barnes KC, Bis JC, Blackwell TW, Boerwinkle E, Burchard EG, Carson AP, Chen Z, Chen YI, Darbar D, de Andrade M, Ellinor PT, Fornage M, Gelb BD, Gilliland FD, He J, Islam T, Kaab S, Kardia SLR, Kelly S, Konkle BA, Kumar R, Loos RJF, Martinez FD, McGarvey ST, Meyers DA, Mitchell BD, Montgomery CG, North KE, Palmer ND, Peralta JM, Raby BA, Redline S, Rich SS, Roden D, Rotter JI, Ruczinski I, Schwartz D, Sciurba F, Shoemaker MB, Silverman EK, Sinner MF, Smith NL, Smith AV, Tiwari HK, Vasan RS, Weiss ST, Williams LK, Zhang Y, Ziv E, Raffield LM, Reiner AP, Arvanitis M, Greider CW, Mathias RA, Battle A

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium · TOPMed Hematology and Hemostasis Working Group · TOPMed Structural Variation Working Group

Nature communications · 2024 · PMID 38789417 · open access

Questions about rs9939870

What is rs9939870?

rs9939870 is a single position in the genome, in or near the TERF2 gene. Published research associates it with leukocyte telomere length. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9939870 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9939870 come from?

GWAS Catalog, Nature communications 2024, PMID:38789417. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Leukocyte telomere length (rs9939870). MyGeneLog™. https://www.mygenelog.com/variants/rs9939870

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