Sensitive

Type 2 diabetes

FTO · rs9936385

Where this position leads

Condition: Type 2 Diabetes

rs9936385 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs9936385 rs9936385 FTO

What the study found

Who was studied 12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ancestry controls; replicated in 21,491 European ancestry cases, 55,647 European ancestry controls.

The effect Each copy of the C allele carried 1.13 times the odds of Type 2 diabetes (95% confidence interval 1.09-1.18); p = 1 × 10−12.

How common The C allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 16, band 16q12.2 — in an intron of FTO.

What each result means

C/C Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/T No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs9936385

What is rs9936385?

rs9936385 is a single position in the genome, in or near the FTO gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9936385 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs9936385?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs9936385 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9936385 come from?

GWAS Catalog, Nat Genet 2014, PMID:24509480. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs9936385). MyGeneLog™. https://www.mygenelog.com/variants/rs9936385

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