Who was studied 257,841 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0243 higher (95% confidence interval 0.018-0.031); p = 6 × 10−13.
How common The A allele had a frequency of about 77% in the people studied.
Where it sits Chromosome 8, band 8q21.3 — between genes, 48.9 kb from RUNX1T1.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cognitive performance compared to the general population.
A/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cognitive performance.
T/TPublished research associates this genotype with typical/baseline likelihood of Cognitive performance — no copies of the reported risk allele.
rs991871 is a single position in the genome, in or near the near RUNX1T1 gene. Published research associates it with cognitive performance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs991871 linked to?
On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.
Does having rs991871 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs991871 come from?
GWAS Catalog, Nat Genet 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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