Sensitive
Barrett's esophagus or Esophageal adenocarcinoma
TPPP · rs9918259
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Barrett's esophagus or Esophageal adenocarcinoma — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Barrett's esophagus or Esophageal adenocarcinoma.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Barrett's esophagus or Esophageal adenocarcinoma compared to the general population.
Source
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis
Gharahkhani P,
Fitzgerald RC,
Vaughan TL,
Palles C,
Gockel I,
Tomlinson I,
Buas MF,
May A,
Gerges C,
Anders M,
Becker J,
Kreuser N
and 57 more — show all
Noder T,
Venerito M,
Veits L,
Schmidt T,
Manner H,
Schmidt C,
Hess T,
Böhmer AC,
Izbicki JR,
Hölscher AH,
Lang H,
Lorenz D,
Schumacher B,
Hackelsberger A,
Mayershofer R,
Pech O,
Vashist Y,
Ott K,
Vieth M,
Weismüller J,
Nöthen MM,
Attwood S,
Barr H,
Chegwidden L,
de Caestecker J,
Harrison R,
Love SB,
MacDonald D,
Moayyedi P,
Prenen H,
Watson RGP,
Iyer PG,
Anderson LA,
Bernstein L,
Chow WH,
Hardie LJ,
Lagergren J,
Liu G,
Risch HA,
Wu AH,
Ye W,
Bird NC,
Shaheen NJ,
Gammon MD,
Corley DA,
Caldas C,
Moebus S,
Knapp M,
Peters WHM,
Neuhaus H,
Rösch T,
Ell C,
MacGregor S,
Pharoah P,
Whiteman DC,
Jankowski J,
Schumacher J
The Lancet. Oncology · 2016 · PMID 27527254 · open access
Questions about rs9918259
What is rs9918259?
rs9918259 is a single position in the genome, in or near the TPPP gene. Published research associates it with barrett's esophagus or esophageal adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs9918259 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9918259 come from?
GWAS Catalog, Lancet Oncol 2016, PMID:27527254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants