Standard

Appendicular lean mass

MYO1C · rs9905106

What the study found

Who was studied 450,243 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.016 higher (95% confidence interval 0.012-0.02); p = 8 × 10−14.

How common The T allele had a frequency of about 26% in the people studied.

Where it sits Chromosome 17, band 17p13.3 — a missense change in MYO1C.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2017-05-09. ClinVar record 508101 NM_001080779.2(MYO1C):c.2477A>G (p.Gln826Arg)

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Appendicular lean mass — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Appendicular lean mass.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Appendicular lean mass compared to the general population.
Source

Questions about rs9905106

What is rs9905106?

rs9905106 is a single position in the genome, in or near the MYO1C gene. Published research associates it with appendicular lean mass. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9905106 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9905106 come from?

GWAS Catalog, Commun Biol 2020, PMID:33097823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Appendicular lean mass (rs9905106). MyGeneLog™. https://www.mygenelog.com/variants/rs9905106

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