Standard
Smoking cessation
NLGN2 · rs9900691
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,400,535 European ancestry, East Asian ancestry, Hispanic or Latin American, African ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.00845 lower (95% confidence interval 0.0058-0.0111); p = 3 × 10−10.
How common The G allele had a frequency of about 28% in the people studied.
Where it sits Chromosome 17, band 17p13.1 — in the 3′ untranslated region of NLGN2.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Smoking cessation — no copies of the reported risk allele.
C/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Smoking cessation.
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Smoking cessation compared to the general population.
Source
Genetic diversity fuels gene discovery for tobacco and alcohol use
Saunders GRB,
Wang X,
Chen F,
Jang SK,
Liu M,
Wang C,
Gao S,
Jiang Y,
Khunsriraksakul C,
Otto JM,
Addison C,
Akiyama M
and 205 more — show all
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Roan C,
Rotter JI,
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Runarsdottir V,
Saccone NL,
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Shadyab AH,
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Shringarpure SS,
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Stallings MC,
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Syed M,
Tal-Singer R,
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Telen MJ,
Thai KK,
Tiwari H,
Turman C,
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Wall TL,
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Nature · 2022 · PMID 36477530 · open access
Questions about rs9900691
What is rs9900691?
rs9900691 is a single position in the genome, in or near the NLGN2 gene. Published research associates it with smoking cessation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs9900691 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9900691 come from?
GWAS Catalog, Nature 2022, PMID:36477530. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Smoking cessation (rs9900691). MyGeneLog™. https://www.mygenelog.com/variants/rs9900691
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