Sensitive

Systemic lupus erythematosus

NEURL4 · rs9899849

Where this position leads

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic lupus erythematosus compared to the general population. (GWAS Catalog, Nat Commun 2021, PMID:33536424)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic lupus erythematosus. (GWAS Catalog, Nat Commun 2021, PMID:33536424)

G/G Published research associates this genotype with typical/baseline likelihood of Systemic lupus erythematosus — no copies of the reported risk allele. (GWAS Catalog, Nat Commun 2021, PMID:33536424)

Source

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

Wang YF, Zhang Y, Lin Z, Zhang H, Wang TY, Cao Y, Morris DL, Sheng Y, Yin X, Zhong SL, Gu X, Lei Y

and 23 more — show all

He J, Wu Q, Shen JJ, Yang J, Lam TH, Lin JH, Mai ZM, Guo M, Tang Y, Chen Y, Song Q, Ban B, Mok CC, Cui Y, Lu L, Shen N, Sham PC, Lau CS, Smith DK, Vyse TJ, Zhang X, Lau YL, Yang W

Nature communications · 2021 · PMID 33536424 · open access

Questions about rs9899849

What is rs9899849?

rs9899849 is a single position in the genome, in or near the NEURL4 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9899849 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs9899849 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9899849 come from?

GWAS Catalog, Nat Commun 2021, PMID:33536424. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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