Sensitive

Systemic lupus erythematosus

ITGAM · rs9888739

Where this position leads

Condition: Systemic Lupus Erythematosus

rs9888739 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs9888739 rs9888739 ITGAM

What the study found

Who was studied 720 European ancestry female cases, 2,337 European ancestry female controls; replicated in 1,846 European ancestry female cases, 1,825 European ancestry female controls.

The effect Each copy of the T allele carried 1.62 times the odds of Systemic lupus erythematosus (95% confidence interval 1.47-1.78); p = 2 × 10−23.

How common The T allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 16, band 16p11.2 — in an intron of ITGAM.

What each result means

C/C No copy of the version the research linked to Systemic lupus erythematosus. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Systemic lupus erythematosus. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9888739

What is rs9888739?

rs9888739 is a single position in the genome, in or near the ITGAM gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9888739 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs9888739 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9888739 come from?

GWAS Catalog, Nat Genet 2008, PMID:18204446. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic lupus erythematosus (rs9888739). MyGeneLog™. https://www.mygenelog.com/variants/rs9888739

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