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Alcohol consumption

BDNF · rs988748

Where this position leads

What the study found

Who was studied 480,842 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.008 lower (95% confidence interval 0.006-0.01); p = 4 × 10⁻⁹.

How common The C allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 11, band 11p14.1 — in an intron of BDNF.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alcohol consumption compared to the general population.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alcohol consumption.

G/G Published research associates this genotype with typical/baseline likelihood of Alcohol consumption — no copies of the reported risk allele.

Source

Evangelou E, Gao H, Chu C, Ntritsos G, Ntritsos G, Blakeley P, Butts AR, Pazoki R, Suzuki H, Koskeridis F, Yiorkas AM, Karaman I

and 88 more — show all

Elliott J, Luo Q, Aeschbacher S, Bartz TM, Baumeister SE, Braund PS, Brown MR, Brody JA, Clarke TK, Dimou N, Faul JD, Homuth G, Jackson AU, Kentistou KA, Joshi PK, Lemaitre RN, Lind PA, Lyytikäinen LP, Mangino M, Milaneschi Y, Nelson CP, Nolte IM, Perälä MM, Polasek O, Porteous D, Ratliff SM, Smith JA, Stančáková A, Teumer A, Tuominen S, Thériault S, Vangipurapu J, Whitfield JB, Wood A, Yao J, Yu B, Zhao W, Zhao W, Arking DE, Auvinen J, Liu C, Männikkö M, Risch L, Rotter JI, Snieder H, Veijola J, Blakemore AI, Boehnke M, Campbell H, Conen D, Eriksson JG, Grabe HJ, Guo X, van der Harst P, Hartman CA, Hayward C, Heath AC, Jarvelin MR, Kähönen M, Kardia SLR, Kühne M, Kuusisto J, Laakso M, Lahti J, Lehtimäki T, McIntosh AM, Mohlke KL, Morrison AC, Martin NG, Oldehinkel AJ, Penninx BWJH, Psaty BM, Raitakari OT, Rudan I, Samani NJ, Scott LJ, Spector TD, Verweij N, Weir DR, Wilson JF, Levy D, Tzoulaki I, Bell JD, Matthews PM, Rothenfluh A, Desrivières S, Schumann G, Elliott P

Nature human behaviour · 2019 · PMID 31358974

Questions about rs988748

What is rs988748?

rs988748 is a single position in the genome, in or near the BDNF gene. Published research associates it with alcohol consumption. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs988748 linked to?

On MyGeneLog this position is linked to Alcohol Consumption. The research behind each link, and its sources, are set out on that condition page.

Does having rs988748 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs988748 come from?

GWAS Catalog, Nat Hum Behav 2019, PMID:31358974. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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