SLC2A2 · rs9873618
Strength of the evidence
Its strongest genetic-study result is p = 10−124, with 8 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 15,226 British ancestry non-diabetics individuals from 6863 families, 948 British ancestry diabetic individuals from 6863 families..
The effect Each copy of the A allele shifted the measure 0.0889 mmol/L lower (95% confidence interval 0.063-0.115); p = 1 × 10−11.
How common The A allele had a frequency of about 29% in the people studied.
Where it sits Chromosome 3, band 3q26.2 — in an intron of SLC2A2.
How common each version is
AG
A 18.2% · G 81.8%
A 19.6% · G 80.4%
A 20.9% · G 79.1%
A 19.2% · G 80.8%
A 19.8% · G 80.2%
A 35.3% · G 64.7%
A 33.5% · G 66.5%
A 36.5% · G 63.5%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs9873618 is a single position in the genome, in or near the SLC2A2 gene. Published research associates it with fasting plasma glucose. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
SLC2A2 carries pharmacogenomic findings for Metformin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Genome Med 2017, PMID:28270201. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Fasting plasma glucose (rs9873618). MyGeneLog™. https://www.mygenelog.com/variants/rs9873618