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Substantia nigra iron levels (R2* MRI)

near TFRC · rs9867473

What the study found

Who was studied 39,533 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0574 lower (95% confidence interval 0.043-0.071); p = 2 × 10−17.

Where it sits Chromosome 3, band 3q29 — between genes, 22.1 kb from TFRC.

What each result means

A/A Two copies of the version the research linked to Substantia nigra iron levels (R2* MRI). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Substantia nigra iron levels (R2* MRI). That is a smaller link than two copies.
C/C No copy of the version the research linked to Substantia nigra iron levels (R2* MRI). This is the starting point the study compared everyone against.
Source

Questions about rs9867473

What is rs9867473?

rs9867473 is a single position in the genome, in or near the near TFRC gene. Published research associates it with substantia nigra iron levels (r2* mri). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9867473 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9867473 come from?

GWAS Catalog, Neurobiology of disease 2024, PMID:38789058. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Substantia nigra iron levels (R2* MRI) (rs9867473). MyGeneLog™. https://www.mygenelog.com/variants/rs9867473

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