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Non-ischemic heart failure (MTAG)

MLF1 · rs9864508

Where this position leads

What the study found

Who was studied 11,742 European ancestry cases, 691,259 European ancestry controls (MTAG boosted by heart function-related trait samples).

The effect Each copy of the C allele shifted the measure 0.00805 higher (95% confidence interval 0.0053-0.0108); p = 2 × 10⁻⁸.

How common The C allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 3, band 3q25.32 — in an intron of MLF1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Non-ischemic heart failure (MTAG) compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Non-ischemic heart failure (MTAG).

T/T Published research associates this genotype with typical/baseline likelihood of Non-ischemic heart failure (MTAG) — no copies of the reported risk allele.

Source

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population

Enzan N, Miyazawa K, Koyama S, Kurosawa R, Ieki H, Yoshida H, Takechi F, Fukuyama M, Osako R, Tomizuka K, Liu X, Ozaki K

and 18 more — show all

Onouchi Y, Matsuda K, Momozawa Y, Aburatani H, Kamatani Y, Yamaguchi T, Akazawa H, Node K, Ellinor PT, Levin MG, Damrauer SM, Voight BF, Joseph J, Sun YV, Terao C, Ninomiya T, Komuro I, Ito K

BioBank Japan Project

Nature communications · 2025 · PMID 41184235 · open access

Questions about rs9864508

What is rs9864508?

rs9864508 is a single position in the genome, in or near the MLF1 gene. Published research associates it with non-ischemic heart failure (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9864508 linked to?

On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.

Does having rs9864508 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9864508 come from?

GWAS Catalog, Nature communications 2025, PMID:41184235. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Non-ischemic heart failure (MTAG) (rs9864508). MyGeneLog™. https://www.mygenelog.com/variants/rs9864508

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