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Pancreatic cancer

TP63 · rs9854771

Where this position leads

Condition: Pancreatic Cancer

rs9854771 Condition: Pancreatic Cancer Pancreatic Cancer Condition rs9854771 rs9854771 TP63

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 7,638 cases, 7,364 controls; replicated in 2,287 cases, 4,205 controls.

The effect Each copy of the G allele carried 1.12 times the odds of Pancreatic cancer (95% confidence interval 1.08-1.18); p = 2 × 10−8.

How common The G allele had a frequency of about 64% in the people studied.

Where it sits Chromosome 3, band 3q28 — in an intron of TP63.

What each result means

A/A No copy of the version the research linked to Pancreatic cancer. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Pancreatic cancer. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Pancreatic cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer
Childs EJ, Mocci E, Campa D, Bracci PM, Gallinger S, Goggins M, Li D, Neale RE, Olson SH, Scelo G, Amundadottir LT, Bamlet WR
and 50 more — show all
Bijlsma MF, Blackford A, Borges M, Brennan P, Brenner H, Bueno-de-Mesquita HB, Canzian F, Capurso G, Cavestro GM, Chaffee KG, Chanock SJ, Cleary SP, Cotterchio M, Foretova L, Fuchs C, Funel N, Gazouli M, Hassan M, Herman JM, Holcatova I, Holly EA, Hoover RN, Hung RJ, Janout V, Key TJ, Kupcinskas J, Kurtz RC, Landi S, Lu L, Malecka-Panas E, Mambrini A, Mohelnikova-Duchonova B, Neoptolemos JP, Oberg AL, Orlow I, Pasquali C, Pezzilli R, Rizzato C, Saldia A, Scarpa A, Stolzenberg-Solomon RZ, Strobel O, Tavano F, Vashist YK, Vodicka P, Wolpin BM, Yu H, Petersen GM, Risch HA, Klein AP
Nature genetics · 2015 · PMID 26098869 · open access

Questions about rs9854771

What is rs9854771?

rs9854771 is a single position in the genome, in or near the TP63 gene. Published research associates it with pancreatic cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9854771 linked to?

On MyGeneLog this position is linked to Pancreatic Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs9854771 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9854771 come from?

GWAS Catalog, Nat Genet 2015, PMID:26098869. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pancreatic cancer (rs9854771). MyGeneLog™. https://www.mygenelog.com/variants/rs9854771

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