Sensitive

Family history of Alzheimer's disease

near LMO4 · rs985256115

Where this position leads

Condition: Alzheimer's Disease

rs985256115 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs985256115 rs985256115 near LMO4

What the study found

Who was studied 996 African ancestry cases, 1,134 African ancestry controls, 1,100 Admixed-American ancestry cases, 31,755 Admixed-American ancestry controls, 7,077 European ancestry cases, 65 European ancestry controls, 285 East or South Asian cases, 2,266 East or South Asian controls, 21 Middle-Eastern ancestry cases, 94 Middle-Eastern ancestry controls.

The effect Each copy of the G allele carried 15.95 times the odds of Family history of Alzheimer's disease (95% confidence interval 6.06-41.96); p = 2 × 10−8.

Where it sits Chromosome 1, band 1p22.3 — in an intron of LINC01364.

What each result means

A/A No copy of the version the research linked to Family history of Alzheimer's disease. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Family history of Alzheimer's disease. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Family history of Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs985256115

What is rs985256115?

rs985256115 is a single position in the genome, in or near the near LMO4 gene. Published research associates it with family history of alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs985256115 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs985256115 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs985256115 come from?

GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2026, PMID:41755704. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Family history of Alzheimer's disease (rs985256115). MyGeneLog™. https://www.mygenelog.com/variants/rs985256115

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