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Asthma

near LRRC3B · rs9836823

Where this position leads

Condition: Asthma

rs9836823 Condition: Asthma Asthma Condition rs9836823 rs9836823 near LRRC3B

What the study found

Who was studied 4,284 Japanese ancestry female cases, 98,503 Japanese ancestry female controls.

The effect Each copy of the G allele carried 0.86 times the odds of Asthma (95% confidence interval 0.821504381-0.906812182); p = 5 × 10−9.

How common The G allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 3, band 3p24.1 — between genes, 86.5 kb from LRRC3B.

What each result means

A/A No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Asthma. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs9836823

What is rs9836823?

rs9836823 is a single position in the genome, in or near the near LRRC3B gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9836823 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs9836823 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9836823 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs9836823). MyGeneLog™. https://www.mygenelog.com/variants/rs9836823

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