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Hip bone size

ERC2 · rs9830173

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 28,900 European ancestry individuals; replicated in 7,912 European ancestry individuals, 5,699 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.055 higher (95% confidence interval 0.041-0.07); p = 8 × 10−14.

How common The C allele had a frequency of about 38% in the people studied.

Where it sits Chromosome 3, band 3p14.3 — in an intron of ERC2.

What each result means

C/C Two copies of the version the research linked to Hip bone size. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Hip bone size. That is a smaller link than two copies.
G/G No copy of the version the research linked to Hip bone size. This is the starting point the study compared everyone against.
Source
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
Styrkarsdottir U, Stefansson OA, Gunnarsdottir K, Thorleifsson G, Lund SH, Stefansdottir L, Juliusson K, Agustsdottir AB, Zink F, Halldorsson GH, Ivarsdottir EV, Benonisdottir S
and 40 more — show all
Jonsson H, Gylfason A, Norland K, Trajanoska K, Boer CG, Southam L, Leung JCS, Tang NLS, Kwok TCY, Lee JSW, Ho SC, Byrjalsen I, Center JR, Lee SH, Koh JM, Lohmander LS, Ho-Pham LT, Nguyen TV, Eisman JA, Woo J, Leung PC, Loughlin J, Zeggini E, Christiansen C, Rivadeneira F, van Meurs J, Uitterlinden AG, Mogensen B, Jonsson H, Ingvarsson T, Sigurdsson G, Benediktsson R, Sulem P, Jonsdottir I, Masson G, Holm H, Norddahl GL, Thorsteinsdottir U, Gudbjartsson DF, Stefansson K
Nature communications · 2019 · PMID 31053729 · open access

Questions about rs9830173

What is rs9830173?

rs9830173 is a single position in the genome, in or near the ERC2 gene. Published research associates it with hip bone size. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9830173 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9830173 come from?

GWAS Catalog, Nature communications 2019, PMID:31053729. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hip bone size (rs9830173). MyGeneLog™. https://www.mygenelog.com/variants/rs9830173

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