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Who was studied 205,483 European ancestry individuals (MTAG effective sample size boosted by aortic valve function samples).
The effect
Each copy of the T allele shifted the measure 0.0291 higher (95% confidence interval 0.022-0.037); p = 3 × 10−14.
How common The T allele had a frequency of about 59% in the people studied.
Where it sits Chromosome 3, band 3p14.3 — between genes, 15.8 kb from PPIAP16.
What each result means
A/ANo copy of the version the research linked to Aortic stenosis (MTAG). This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Aortic stenosis (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Aortic stenosis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41419685 · open access
Questions about rs9826313
What is rs9826313?
rs9826313 is a single position in the genome, in or near the near PPIAP16 gene. Published research associates it with aortic stenosis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9826313 linked to?
On MyGeneLog this position is linked to Aortic Stenosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs9826313 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9826313 come from?
GWAS Catalog, Nature genetics 2026, PMID:41419685. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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