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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0143 lower (95% confidence interval 0.01-0.018); p = 7 × 10−13.
How common The C allele had a frequency of about 40% in the people studied.
Where it sits Chromosome 10, band 10q23.31 — inside FAS.
What each result means
C/CTwo copies of the version the research linked to Lymphocyte percentage (UKB data field 30180). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Lymphocyte percentage (UKB data field 30180). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Lymphocyte percentage (UKB data field 30180). This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs978522
What is rs978522?
rs978522 is a single position in the genome, in or near the FAS gene. Published research associates it with lymphocyte percentage (ukb data field 30180). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs978522 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs978522 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs978522 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 8125Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lymphocyte percentage (UKB data field 30180) (rs978522). MyGeneLog™. https://www.mygenelog.com/variants/rs978522