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Who was studied 215,551 European ancestry individuals, 57,332 African American individuals, 24,743 Hispanic individuals; replicated in Up to 319,677 individuals.
The effect
Each copy of the T allele shifted the measure 0.022 mg dl-1 higher (95% confidence interval 0.017-0.027); p = 2 × 10−16.
How common The T allele had a frequency of about 59% in the people studied.
Where it sits Chromosome 4, band 4q13.2 — in an intron of TMPRSS11E.
What each result means
C/CNo copy of the version the research linked to LDL cholesterol. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to LDL cholesterol. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to LDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2018 · PMID 30275531 · open access
Questions about rs976058
What is rs976058?
rs976058 is a single position in the genome, in or near the TMPRSS11E gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs976058 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs976058 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs976058 come from?
GWAS Catalog, Nature genetics 2018, PMID:30275531. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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