Gene Knowledge Graph
UTC
Sensitive

Colorectal cancer

near RNA5SP299 · rs9733843

Where this position leads

Condition: Colorectal Cancer

rs9733843 Condition: Colorectal Cancer Colorectal Cancer Condition rs9733843 rs9733843 near RNA5SP2…

What the study found

Who was studied 7,062 Japanese ancestry cases, 195,745 Japanese ancestry controls.

The effect Each copy of the G allele carried 0.87 times the odds of Colorectal cancer (95% confidence interval 0.840056322-0.901347604); p = 1 × 10−14.

How common The G allele had a frequency of about 38% in the people studied.

Where it sits Chromosome 10, band 10p14 — between genes, 19.2 kb from RNA5SP299.

What each result means

A/A No copy of the version the research linked to Colorectal cancer. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Colorectal cancer. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Colorectal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs9733843

What is rs9733843?

rs9733843 is a single position in the genome, in or near the near RNA5SP299 gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9733843 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs9733843 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9733843 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Colorectal cancer (rs9733843). MyGeneLog™. https://www.mygenelog.com/variants/rs9733843

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