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Total cholesterol levels

near EIF4B · rs9705954

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0115 higher (95% confidence interval 0.0078-0.0152); p = 8 × 10−10.

Where it sits Chromosome 12, band 12q13.13 — between genes, 10.6 kb from EIF4B.

What each result means

C/C Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
Source

Questions about rs9705954

What is rs9705954?

rs9705954 is a single position in the genome, in or near the near EIF4B gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9705954 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9705954 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Total cholesterol levels (rs9705954). MyGeneLog™. https://www.mygenelog.com/variants/rs9705954

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