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Who was studied 365,998 European ancestry individuals, 63,490 African ancestry individuals, 22,802 Hispanic individuals, 4,792 Asian ancestry individuals, 2,695 Native American ancestry individuals; replicated in 299,024 European ancestry individuals, 17,277 individuals.
The effect
Each copy of the C allele shifted the measure 0.142 mmHg lower (95% confidence interval 0.094-0.19); p = 7 × 10−9.
How common The C allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 1, band 1p22.3 — in an intron of CCN1.
What ClinVar records
ClassificationBenign for Uterine carcinosarcoma; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2018-11-12.
ClinVar record 1178850NM_001554.5(CCN1):c.277+50G>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Pulse pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Pulse pressure. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Pulse pressure. This is the starting point the study compared everyone against.
Nature genetics · 2019 · PMID 30578418 · open access
Questions about rs9658584
What is rs9658584?
rs9658584 is a single position in the genome, in or near the CYR61 gene. Published research associates it with pulse pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9658584 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs9658584 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9658584 come from?
GWAS Catalog, Nat Genet 2018, PMID:30578418. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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