Sensitive

Alzheimer's disease (age of onset)

near TAS2R60 · rs9640386

Where this position leads

Condition: Alzheimer's Disease

rs9640386 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs9640386 rs9640386 near TAS2R60

What the study found

Who was studied 27,993 European ancestry individuals, 6,949 Black individuals, 6,530 Hispanic individuals, 55 individuals.

The effect Each copy of the A allele shifted the measure 0.031 higher (95% confidence interval 0.021-0.041); p = 1 × 10−9.

How common The A allele had a frequency of about 57% in the people studied.

Where it sits Chromosome 7, band 7q35 — in an intron of EPHA1-AS1.

What each result means

A/A Two copies of the version the research linked to Alzheimer's disease (age of onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Alzheimer's disease (age of onset). That is a smaller link than two copies.
G/G No copy of the version the research linked to Alzheimer's disease (age of onset). This is the starting point the study compared everyone against.
Source

Questions about rs9640386

What is rs9640386?

rs9640386 is a single position in the genome, in or near the near TAS2R60 gene. Published research associates it with alzheimer's disease (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9640386 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs9640386 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9640386 come from?

GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:40883957. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease (age of onset) (rs9640386). MyGeneLog™. https://www.mygenelog.com/variants/rs9640386

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