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Serum carcinoembryonic antigen levels

CEACAM5 · rs9621

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 22,309 Icelandic ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.71 higher (95% confidence interval 0.67-0.76); p = 5 × 10−201.

How common The A allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 19, band 19q13.2 — a missense change in CEACAM5.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Serum carcinoembryonic antigen levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Serum carcinoembryonic antigen levels.
G/G Published research associates this genotype with typical/baseline likelihood of Serum carcinoembryonic antigen levels — no copies of the reported risk allele.
Source
Common and Rare Sequence Variants Influencing Tumor Biomarkers in Blood
Olafsson S, Alexandersson KF, Gizurarson JGK, Hauksdottir K, Gunnarsson O, Olafsson K, Gudmundsson J, Stacey SN, Sveinbjornsson G, Saemundsdottir J, Bjornsson ES, Olafsson S
and 22 more — show all
Bjornsson S, Orvar KB, Vikingsson A, Geirsson AJ, Arinbjarnarson S, Bjornsdottir G, Thorgeirsson TE, Sigurdsson S, Halldorsson GH, Magnusson OT, Masson G, Holm H, Jonsdottir I, Sigurdardottir O, Eyjolfsson GI, Olafsson I, Sulem P, Thorsteinsdottir U, Jonsson T, Rafnar T, Gudbjartsson DF, Stefansson K
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020 · PMID 31666285

Questions about rs9621

What is rs9621?

rs9621 is a single position in the genome, in or near the CEACAM5 gene. Published research associates it with serum carcinoembryonic antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9621 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9621 come from?

GWAS Catalog, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2020, PMID:31666285. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Serum carcinoembryonic antigen levels (rs9621). MyGeneLog™. https://www.mygenelog.com/variants/rs9621

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