Sensitive

Uterine leiomyoma or ER negative breast cancer (pleiotropy)

TNRC6B · rs9611271

Where this position leads

Condition: Breast Cancer

rs9611271 Condition: Breast Cancer Breast Cancer Condition rs9611271 rs9611271 TNRC6B

What the study found

Who was studied 35,474 European ancestry UL cases, 21,468 European ancestry ER-ve BC cases, 373,479 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 1 × 10−9.

Where it sits Chromosome 22, band 22q13.1 — in an intron of TNRC6B.

What each result means

A/A Two copies of the version the research linked to Uterine leiomyoma or ER negative breast cancer (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Uterine leiomyoma or ER negative breast cancer (pleiotropy). That is a smaller link than two copies.
G/G No copy of the version the research linked to Uterine leiomyoma or ER negative breast cancer (pleiotropy). This is the starting point the study compared everyone against.
Source

Questions about rs9611271

What is rs9611271?

rs9611271 is a single position in the genome, in or near the TNRC6B gene. Published research associates it with uterine leiomyoma or er negative breast cancer (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9611271 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs9611271 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9611271 come from?

GWAS Catalog, American journal of human genetics 2022, PMID:35803233. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Uterine leiomyoma or ER negative breast cancer (pleiotropy) (rs9611271). MyGeneLog™. https://www.mygenelog.com/variants/rs9611271

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