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Who was studied 403,993 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0398 higher (95% confidence interval 0.029-0.051); p = 4 × 10−13.
Where it sits Chromosome 22, band 22q11.1 — in the 3′ untranslated region of TMEM121B.
What each result means
C/CNo copy of the version the research linked to Monocyte count variance. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Monocyte count variance. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Monocyte count variance. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40335489 · open access
Questions about rs9605219
What is rs9605219?
rs9605219 is a single position in the genome, in or near the TMEM121B gene. Published research associates it with monocyte count variance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9605219 linked to?
On MyGeneLog this position is linked to Monocyte Count. The research behind each link, and its sources, are set out on that condition page.
Does having rs9605219 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9605219 come from?
GWAS Catalog, Nature communications 2025, PMID:40335489. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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