near IREB2 · rs951984
Where this position leads
Condition: Lung Cancer
What the study found
Who was studied 59,774 European ancestry cases, 1,416,415 European ancestry controls, 11,773 East Asian ancestry cases, 288,419 East Asian ancestry controls, 4,782 African ancestry cases, 122,496 African ancestry controls, 624 Hispanic/Latino American ancestry cases, 59,042 Hispanic/Latino American ancestry controls.
The effect Each copy of the A allele shifted the measure 0.176 higher (95% confidence interval 0.16-0.19); p = 2 × 10−123.
How common The A allele had a frequency of about 28% in the people studied.
Where it sits Chromosome 15, band 15q25.1 — between genes, 8.9 kb from IREB2.
2026-06-27 · Zhang Y, et al. Nature Communications 2026, PMID:42364979
Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer
Zhang Y, et al. (Nature Communications, 2026) is newly in the GWAS Catalog, with 87 associations across 1 trait ("Lung cancer"). The catalogue records its sample as 76,329 cases and 1,886,372 controls. 21 of the study's 87 positions are already on this site — 13 on the Lung Cancer page; 1 on the Prostate Cancer page; 1 on the Celiac Disease page — including rs951984 (near IREB2), rs37005 (LINC01511), rs12907065 (MORF4L1). This item was assembled by code from the catalogue's records; the paper is linked for the rest. PMID:42364979.
rs951984 is a single position in the genome, in or near the near IREB2 gene. Published research associates it with lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2026, PMID:42364979. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung cancer (rs951984). MyGeneLog™. https://www.mygenelog.com/variants/rs951984