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Smoking initiation

CLYBL · rs9517908

What the study found

Who was studied 3,382,012 European ancestry, East Asian ancestry, Hispanic or Latin American, African ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0121 lower (95% confidence interval 0.01-0.014); p = 7 × 10−40.

How common The A allele had a frequency of about 77% in the people studied.

Where it sits Chromosome 13, band 13q32.3 — in an intron of CLYBL.

What each result means

A/A Two copies of the version the research linked to Smoking initiation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Smoking initiation. That is a smaller link than two copies.
G/G No copy of the version the research linked to Smoking initiation. This is the starting point the study compared everyone against.
Source

Questions about rs9517908

What is rs9517908?

rs9517908 is a single position in the genome, in or near the CLYBL gene. Published research associates it with smoking initiation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9517908 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9517908 come from?

GWAS Catalog, Nature 2022, PMID:36477530. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Smoking initiation (rs9517908). MyGeneLog™. https://www.mygenelog.com/variants/rs9517908

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