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Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied Up to 11,988 European ancestry cases, up to 275,335 European ancestry controls; replicated in 7,044 European ancestry cases, 11,434 European ancestry controls.
The effect
Each copy of the G allele carried 1.12 times the odds of Psoriasis (95% confidence interval -); p = 4 × 10−8.
How common The G allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 13, band 13q32.3 — in an intron of GPR183.
What each result means
A/ANo copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2017 · PMID 28537254 · open access
Questions about rs9513593
What is rs9513593?
rs9513593 is a single position in the genome, in or near the UBAC2 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9513593 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs9513593 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9513593 come from?
GWAS Catalog, Nat Commun 2017, PMID:28537254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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