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Psoriasis

EXOC2 · rs9504361

Where this position leads

Condition: Psoriasis

rs9504361 Condition: Psoriasis Psoriasis Condition rs9504361 rs9504361 EXOC2

What the study found

Who was studied 10,588 European ancestry cases, 22,806 European ancestry controls.

The effect Each copy of the A allele carried 1.12 times the odds of Psoriasis (95% confidence interval -); p = 2 × 10−11.

How common The A allele had a frequency of about 55% in the people studied.

Where it sits Chromosome 6, band 6p25.3 — in an intron of EXOC2.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH
and 53 more — show all
McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC
Collaborative Association Study of Psoriasis (CASP) · Genetic Analysis of Psoriasis Consortium · Psoriasis Association Genetics Extension · Wellcome Trust Case Control Consortium 2
Nature genetics · 2012 · PMID 23143594 · open access

Questions about rs9504361

What is rs9504361?

rs9504361 is a single position in the genome, in or near the EXOC2 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9504361 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs9504361 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9504361 come from?

GWAS Catalog, Nat Genet 2012, PMID:23143594. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs9504361). MyGeneLog™. https://www.mygenelog.com/variants/rs9504361

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