2 4222132224123Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity3Meta AI2Microsoft · Copilot2Amazon2Apple4China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others23Total42Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 133,492 European ancestry individuals with intraocular pressure measurements, 90,939 European ancestry individuals with vertical cup-disc ratio measurements, 7,947 British ancestry glaucoma cases, 119,318 British ancestry controls; replicated in 6,924 European ancestry glaucoma cases, 40,230 European ancestry controls.
The effect
Each copy of the T allele carried 1.10 times the odds of Glaucoma (multi-trait analysis); p = 7 × 10−17.
How common The T allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 6, band 6q23.3 — in an intron of PDE7B.
What each result means
A/ANo copy of the version the research linked to Glaucoma (multi-trait analysis). This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Glaucoma (multi-trait analysis). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Glaucoma (multi-trait analysis). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs9494457 is a single position in the genome, in or near the PDE7B gene. Published research associates it with glaucoma (multi-trait analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9494457 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs9494457 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9494457 come from?
GWAS Catalog, Nat Genet 2020, PMID:31959993. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 4222132224123Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity3Meta AI2Microsoft · Copilot2Amazon2Apple4China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others23Total42Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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