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Septic shock

AL589740.1 · rs9489328

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 493 European ancestry cases, 2,442 European ancestry controls.

The effect Each copy of the G allele carried 2.70 times the odds of Septic shock (95% confidence interval 2.41-2.99); p = 1 × 10⁻¹⁰.

How common The G allele had a frequency of about 90% in the people studied.

Where it sits Chromosome 6, band 6q16.1 — between genes, 367.8 kb from MIR2113.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Septic shock compared to the general population.

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Septic shock.

T/T Published research associates this genotype with typical/baseline likelihood of Septic shock — no copies of the reported risk allele.

Source

Septic Shock: A Genomewide Association Study and Polygenic Risk Score Analysis

D'Urso S, Rajbhandari D, Peach E, de Guzman E, Li Q, Medland SE, Gordon SD, Martin NG, Ligthart S, Brown MA, Powell J, McArthur C

and 9 more — show all

Rhodes A, Meyer J, Finfer S, Myburgh J, Blumenthal A, Cohen J, Venkatesh B, Cuellar-Partida G, Evans DM

CHARGE Inflammation Working Group

Twin research and human genetics : the official journal of the International Society for Twin Studies · 2020 · PMID 32755526

Questions about rs9489328

What is rs9489328?

rs9489328 is a single position in the genome, in or near the AL589740.1 gene. Published research associates it with septic shock. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9489328 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9489328 come from?

GWAS Catalog, Twin Res Hum Genet 2020, PMID:32755526. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Septic shock (rs9489328). MyGeneLog™. https://www.mygenelog.com/variants/rs9489328

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