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High light scatter reticulocyte percentage of red cells

FOXO3 · rs9480866

Where this position leads

Condition: Blood Cell Counts

rs9480866 Condition: Blood Cell Counts Blood Cell Counts Condition rs9480866 rs9480866 FOXO3

What the study found

Who was studied 170,763 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0335 (percentage) lower (95% confidence interval 0.024-0.043); p = 1 × 10−11.

How common The T allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 6, band 6q21 — in an intron of FOXO3.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of High light scatter reticulocyte percentage of red cells — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with High light scatter reticulocyte percentage of red cells.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of High light scatter reticulocyte percentage of red cells compared to the general population.
Source

Questions about rs9480866

What is rs9480866?

rs9480866 is a single position in the genome, in or near the FOXO3 gene. Published research associates it with high light scatter reticulocyte percentage of red cells. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9480866 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs9480866 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9480866 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

High light scatter reticulocyte percentage of red cells (rs9480866). MyGeneLog™. https://www.mygenelog.com/variants/rs9480866

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