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Psoriasis

near OR2N1P · rs9468487

Where this position leads

Condition: Psoriasis

rs9468487 Condition: Psoriasis Psoriasis Condition rs9468487 rs9468487 near OR2N1P

What the study found

Who was studied 20,105 European ancestry cases, 842,975 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.265 lower (95% confidence interval 0.2-0.33); p = 4 × 10−15.

How common The A allele had a frequency of about 96% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — between genes, 0.5 kb from OR2N1P.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source
Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization
Liu S, Li L, Liang Y, Tan Y, Wang X, Feng Y, Chen N, Lei X
Briefings in bioinformatics · 2024 · PMID 39883516 · open access

Questions about rs9468487

What is rs9468487?

rs9468487 is a single position in the genome, in or near the near OR2N1P gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9468487 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs9468487 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9468487 come from?

GWAS Catalog, Briefings in bioinformatics 2024, PMID:39883516. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs9468487). MyGeneLog™. https://www.mygenelog.com/variants/rs9468487

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