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Standard

Total cholesterol levels

TRAM2-AS1 · rs9463799

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−13, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0126 lower (95% confidence interval 0.0098-0.0154); p = 2 × 10−13.

How common The G allele had a frequency of about 35% in the people studied.

Where it sits Chromosome 6, band 6p12.2 — in an intron of TRAM2-AS1.

How common each version is

AG
Korean KRGDB
A 74.2% · G 25.8%
Korean Korea4K
A 74.5% · G 25.5%
Korean Korea1K
A 73.2% · G 26.8%
Japanese ToMMo
A 75.6% · G 24.4%
Vietnamese
A 72.9% · G 27.1%
World gnomAD
A 67.4% · G 32.6%
World 1000 Genomes
A 69.3% · G 30.7%
World TOPMed
A 69.1% · G 30.9%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Total cholesterol levels (rs9463799). MyGeneLog™. https://www.mygenelog.com/variants/rs9463799

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