Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection
HLA-DQA1 · rs9461776
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Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 356 European ancestry cases, 447 European ancestry controls; replicated in 92 European ancestry cases, 179 European ancestry controls.
The effect
Each copy of the G allele carried 2.02 times the odds of Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection; p = 7 × 10−9.
How common The G allele had a frequency of about 29% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 18.1 kb from HLA-DRB1.
What each result means
A/ANo copy of the version the research linked to Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs9461776
What is rs9461776?
rs9461776 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with mixed cryoglobulinemia vasculitis in chronic hepatitis c infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9461776 linked to?
On MyGeneLog this position is linked to Chronic Hepatitis C. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs9461776?
Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs9461776 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9461776 come from?
GWAS Catalog, Genes Immun 2014, PMID:25030430. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 5022425222128Reads by AI crawlersClaude2ChatGPT2Google · Gemini4Perplexity2Meta AI5Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others28Total50Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection (rs9461776). MyGeneLog™. https://www.mygenelog.com/variants/rs9461776