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Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection

HLA-DQA1 · rs9461776

Where this position leads

Condition: Chronic Hepatitis C

rs9461776 Condition: Chronic Hepatitis C Chronic Hepatitis C Condition Topic: Infection and immunity Infection and immunity Topic rs9461776 rs9461776 HLA-DQA1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection compared to the general population.
Source
Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis
Zignego AL, Wojcik GL, Cacoub P, Visentini M, Casato M, Mangia A, Latanich R, Charles ED, Gragnani L, Terrier B, Piazzola V, Dustin LB
and 7 more — show all
Khakoo SI, Busch MP, Lauer GM, Kim AY, Alric L, Thomas DL, Duggal P
Genes and immunity · 2014 · PMID 25030430

What people read about alongside this

Infection and immunity3

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs9461776

What is rs9461776?

rs9461776 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with mixed cryoglobulinemia vasculitis in chronic hepatitis c infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9461776 linked to?

On MyGeneLog this position is linked to Chronic Hepatitis C. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs9461776?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs9461776 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9461776 come from?

GWAS Catalog, Genes Immun 2014, PMID:25030430. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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