Standard

Inguinal hernia

near SPSB1 · rs9435183

Where this position leads

What the study found

Who was studied 461 African American or African ancestry cases, 10,141 African American or African ancestry controls, 33,379 European ancestry cases, 436,717 European ancestry controls, 433 East Asian ancestry cases, 8,318 East Asian ancestry controls, 725 Hispanic or Latin American cases, 6,883 Hispanic or Latin American controls, 435 South Asian ancestry cases, 8,482 South Asian ancestry controls, 341 mixed ancestry cases, 6,805 mixed ancestry controls; replicated in 559 African American or African ancestry cases, 23,053 African American or African ancestry controls, 30,322 European ancestry cases, 580,593 European ancestry controls, 174 East Asian ancestry cases, 12,619 East Asian ancestry controls, 2,341 Hispanic or Latin American cases, 75,507 Hispanic or Latin American controls, 95 South Asian ancestry cases, 3,155 South Asian ancestry controls.

The effect The reported allele is C; the catalogue records no effect size ; p = 5 × 10⁻¹⁰.

Where it sits Chromosome 1, band 1p36.22 — between genes, 8.6 kb from SPSB1.

What each result means

C/C Two copies of the version the research linked to Inguinal hernia. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Inguinal hernia. That is a smaller link than two copies.

T/T No copy of the version the research linked to Inguinal hernia. This is the starting point the study compared everyone against.

Source

Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis

Choquet H, Li W, Yin J, Bradley R, Hoffmann TJ, Nandakumar P, Mostaedi R, Tian C, Ahituv N, Jorgenson E

23 and Me Research Team

Human molecular genetics · 2022 · PMID 35022708 · open access

Questions about rs9435183

What is rs9435183?

rs9435183 is a single position in the genome, in or near the near SPSB1 gene. Published research associates it with inguinal hernia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9435183 linked to?

On MyGeneLog this position is linked to Inguinal Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs9435183 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9435183 come from?

GWAS Catalog, Human molecular genetics 2022, PMID:35022708. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Inguinal hernia (rs9435183). MyGeneLog™. https://www.mygenelog.com/variants/rs9435183

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