Standard

PDL-1 on monocyte

FCGR2A · rs9427401

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 3,629 Sardinian (founder/genetic isolate) ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.273 lower (95% confidence interval 0.22-0.33); p = 2 × 10⁻²⁰.

How common The G allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 1, band 1q23.3 — in an intron of FCGR2A.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of PDL-1 on monocyte — no copies of the reported risk allele.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with PDL-1 on monocyte.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of PDL-1 on monocyte compared to the general population.

Source

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, Sole G, Lai S, Dei M, Mulas A, Virdis F, Piras MG

and 16 more — show all

Lobina M, Marongiu M, Pitzalis M, Deidda F, Loizedda A, Onano S, Zoledziewska M, Sawcer S, Devoto M, Gorospe M, Abecasis GR, Floris M, Pala M, Schlessinger D, Fiorillo E, Cucca F

Nature genetics · 2020 · PMID 32929287

Questions about rs9427401

What is rs9427401?

rs9427401 is a single position in the genome, in or near the FCGR2A gene. Published research associates it with pdl-1 on monocyte. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9427401 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9427401 come from?

GWAS Catalog, Nature genetics 2020, PMID:32929287. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

PDL-1 on monocyte (rs9427401). MyGeneLog™. https://www.mygenelog.com/variants/rs9427401

← See all variants