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Gout

TRIM46 · rs9426886

Where this position leads

Condition: Gout

What the study found

Who was studied 100,671 European ancestry cases, 2,106,212 European ancestry controls.

The effect Each copy of the A allele carried 1.09 times the odds of Gout (95% confidence interval 1.08-1.1); p = 2 × 10⁻⁶⁹.

How common The A allele had a frequency of about 58% in the people studied.

Where it sits Chromosome 1, band 1q22 — in an intron of TRIM46.

What each result means

A/A Two copies of the version the research linked to Gout. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to Gout. That is a smaller link than two copies.

T/T No copy of the version the research linked to Gout. This is the starting point the study compared everyone against.

Source

A genome-wide association analysis reveals new pathogenic pathways in gout

Major TJ, Takei R, Matsuo H, Leask MP, Sumpter NA, Topless RK, Shirai Y, Wang W, Cadzow MJ, Phipps-Green AJ, Li Z, Ji A

and 86 more — show all

Merriman ME, Morice E, Kelley EE, Wei WH, McCormick SPA, Bixley MJ, Reynolds RJ, Saag KG, Fadason T, Golovina E, O'Sullivan JM, Stamp LK, Dalbeth N, Abhishek A, Doherty M, Roddy E, Jacobsson LTH, Kapetanovic MC, Melander O, Andrés M, Pérez-Ruiz F, Torres RJ, Radstake T, Jansen TL, Janssen M, Joosten LAB, Liu R, Gaal OI, Crişan TO, Rednic S, Kurreeman F, Huizinga TWJ, Toes R, Lioté F, Richette P, Bardin T, Ea HK, Pascart T, McCarthy GM, Helbert L, Stibůrková B, Tausche AK, Uhlig T, Vitart V, Boutin TS, Hayward C, Riches PL, Ralston SH, Campbell A, MacDonald TM, Nakayama A, Takada T, Nakatochi M, Shimizu S, Kawamura Y, Toyoda Y, Nakaoka H, Yamamoto K, Matsuo K, Shinomiya N, Ichida K, Lee C, Bradbury LA, Brown MA, Robinson PC, Buchanan RRC, Hill CL, Lester S, Smith MD, Rischmueller M, Choi HK, Stahl EA, Miner JN, Solomon DH, Cui J, Giacomini KM, Brackman DJ, Jorgenson EM, Liu H, Susztak K, Shringarpure S, So A, Okada Y, Li C, Shi Y, Merriman TR

FAST Study Group · Japan Gout Genomics Consortium · Asia Pacific Gout Consortium · GlobalGout Genetics Consortium · 23andMe Research Team

Nature genetics · 2024 · PMID 39406924

Questions about rs9426886

What is rs9426886?

rs9426886 is a single position in the genome, in or near the TRIM46 gene. Published research associates it with gout. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9426886 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs9426886 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9426886 come from?

GWAS Catalog, Nature genetics 2024, PMID:39406924. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gout (rs9426886). MyGeneLog™. https://www.mygenelog.com/variants/rs9426886

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