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Smoking initiation (ever regular vs never regular)

CPXM2 · rs9423279

Where this position leads

Condition: Smoking Behaviour and Nicotine Dependence

rs9423279 Condition: Smoking Behaviour and Nicotine Dependence Smoking Behaviour and Nicotine Dependence Condition rs9423279 rs9423279 CPXM2

What the study found

Who was studied up to 433,216 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0139 lower (95% confidence interval 0.0092-0.0186); p = 8 × 10−9.

How common The G allele had a frequency of about 66% in the people studied.

Where it sits Chromosome 10, band 10q26.13 — in an intron of CPXM2.

What each result means

C/C No copy of the version the research linked to Smoking initiation (ever regular vs never regular). This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Smoking initiation (ever regular vs never regular). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Smoking initiation (ever regular vs never regular). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD, Liu M, Barnes DR, Bertelsen S, Chou YL
and 59 more — show all
Erzurumluoglu AM, Faul JD, Haessler J, Hammerschlag AR, Hsu C, Kapoor M, Lai D, Le N, de Leeuw CA, Loukola A, Mangino M, Melbourne CA, Pistis G, Qaiser B, Rohde R, Shao Y, Stringham H, Wetherill L, Zhao W, Agrawal A, Bierut L, Chen C, Eaton CB, Goate A, Haiman C, Heath A, Iacono WG, Martin NG, Polderman TJ, Reiner A, Rice J, Schlessinger D, Scholte HS, Smith JA, Tardif JC, Tindle HA, van der Leij AR, Boehnke M, Chang-Claude J, Cucca F, David SP, Foroud T, Howson JMM, Kardia SLR, Kooperberg C, Laakso M, Lettre G, Madden P, McGue M, North K, Posthuma D, Spector T, Stram D, Tobin MD, Weir DR, Kaprio J, Abecasis GR, Liu DJ, Vrieze S
CHD Exome+ Consortium · Consortium for Genetics of Smoking Behaviour
Biological psychiatry · 2019 · PMID 30679032

Questions about rs9423279

What is rs9423279?

rs9423279 is a single position in the genome, in or near the CPXM2 gene. Published research associates it with smoking initiation (ever regular vs never regular). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9423279 linked to?

On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.

Does having rs9423279 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9423279 come from?

GWAS Catalog, Biol Psychiatry 2018, PMID:30679032. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Smoking initiation (ever regular vs never regular) (rs9423279). MyGeneLog™. https://www.mygenelog.com/variants/rs9423279

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