Sensitive

Gastroesophageal reflux disease

UNC79 · rs942065

What the study found

Who was studied 129,080 European ancestry cases, 473,524 European ancestry controls; replicated in 462,753 cases, 1,127,474 controls.

The effect Each copy of the G allele shifted the measure 0.031 lower; p = 8 × 10−10.

How common The G allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 14, band 14q32.12 — in an intron of UNC79.

What each result means

A/A No copy of the version the research linked to Gastroesophageal reflux disease. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Gastroesophageal reflux disease. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Gastroesophageal reflux disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs942065

What is rs942065?

rs942065 is a single position in the genome, in or near the UNC79 gene. Published research associates it with gastroesophageal reflux disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs942065 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs942065 come from?

GWAS Catalog, Gut 2022, PMID:34187846. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gastroesophageal reflux disease (rs942065). MyGeneLog™. https://www.mygenelog.com/variants/rs942065

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