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Atrial fibrillation

HSF2 · rs9401451

Where this position leads

Condition: Atrial Fibrillation

rs9401451 Condition: Atrial Fibrillation Atrial Fibrillation Condition rs9401451 rs9401451 HSF2

What the study found

Who was studied 60,620 European ancestry cases, 970,216 European ancestry controls.

The effect Each copy of the G allele carried 1.08 times the odds of Atrial fibrillation (95% confidence interval 1.05-1.10); p = 3 × 10−11.

How common The G allele had a frequency of about 90% in the people studied.

Where it sits Chromosome 6, band 6q22.31 — in an intron of LOC105377979.

What each result means

A/A No copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9401451

What is rs9401451?

rs9401451 is a single position in the genome, in or near the HSF2 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9401451 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

Does having rs9401451 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9401451 come from?

GWAS Catalog, Nat Genet 2018, PMID:30061737. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Atrial fibrillation (rs9401451). MyGeneLog™. https://www.mygenelog.com/variants/rs9401451

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